there is a definite correlation between cardiovascular diseases and depressive disorders. nevertheless, many aspects of this association have yet to be fully elucidated. up to half of coronary artery disease patients are liable to suffer from some depressive symptoms, with approximately 20% receiving a diagnosis of major depressive disorders. pharmacotherapy is a key factor in the management of...

background major depressive disorder (mdd) is the most common disorder in our community. hypericum perforatumm, is a herb with a long application history in treating depression. a controlled study to evaluate the effects of this herbal medicine in iran did not exist. objectives this study aimed to assess the effect of hypericum perforatom (perforan), in combination with tricyclic antidepressant...

Among patients with cardiovascular disease (CVD), depression is highly prevalent and is associated with worse cardiovascular prognosis and lower quality of life. Treatments for depression in CVD patients produce modest, but clinically significant reductions in depressive symptoms and show promise for improving cardiovascular prognosis. While tricyclics should generally be avoided, antidepressan...

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays significant role in the survival and development of neurons, being involved several diseases such as Alzheimer’s disease major depression disorder. The association between BDNF depressive disorder subject extensive research. Indeed, numerous studies indicate decreased levels are linked to an increased occurrence symptoms, neu...

general population surveys often report that only a small proportion of individuals with common mental disorders seek mental health treatment, suggesting a high level of unmet need for mental health care in the community. in recent years, however, the number of adults in industrialized countries who are treated with antidepressant medications has dramatically increased. this paper reviews the p...

Depressive disorder occurs frequently in response to the onset of several cardiovascular diseases, particularly in the post-myocardial infarction period, and can become an important determinant of prognosis or recovery. In patients whose heart disease or hypertension is managed by a cardiologist or primary care physician, depressive disorder is apt to go undiagnosed and therefore untreated. The...

BACKGROUND Subclinical hypothyroidism has been associated with depressive symptoms in cross-sectional studies, but prospective data and data on subclinical hyperthyroidism are scarce. METHODS In the Leiden substudy of the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER), thyroid-stimulating hormone and free T4 levels were measured at baseline and repeated after 6 months in ad...

The relationship of our emotions and psyche to heart disease is intriguing. In this article we have reviewed the evidence linking cardiovascular and neuropsychiatric disorders and the possible mechanisms and pathophysiology of this association. This review is derived from Medline searches (1966-2002) using the relevant search terms (psychiatric disease, cardiovascular disease, depression, anxie...

BACKGROUND A change in number and/or activity of natural killer cells has repeatedly been reported in depressive illness. Much less attention has yet been given to the subgroup of natural killer cells that are positive for the T-cell marker CD3 (NK-T cells). These cells possibly have important immunoregulatory properties. METHODS We compared number and percentage of NK-T cells (defined as CD3...